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Elevated Cortisol and Prolactin Levels: May result in stress-related symptoms, decreased libido, and gynecomastia in men

The enzyme CHAC1 (CHAC1/BOTCH for blocking NOTCH) is a key regulator of this process (Figure 6)

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It has also been reported that the -glutamylcysteine synthetase is not the limiting step in plants under heavy metal stress conditions and overexpression of a bacterial glutathione synthetase gene alone in Indian mustard results in higher concentrations of glutathione in the transgenic plant 31